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HG-7-85-01

CAT: 0931-T38653-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T38653-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1258391-13-7
Target
JAK, Apoptosis, PDGFR, c-Kit, Src, Bcr-Abl
Related Pathways
JAK/STAT signaling, Stem Cells, Cytoskeletal Signaling, Apoptosis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9808
Bioactivity
HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases, with inhibitory effects on the proliferation of a variety of cancer cell lines, leading to G0/G1-phase blockade and apoptosis induction in BCR-ABL-expressing cells.
Smiles
O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=CC(=C3)C4=NC=5SC(=NC5C=C4)NC(=O)C6CC6
Molecular Formula
C31H31F3N6O2S
Molecular Weight
608.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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