HG-10-102-01

• UNSPSC Description:

  HG-10-102-01 is a highly potent, selective, and brain-penetrable LRRK2 inhibitor, with IC50 values of 20.3 and 3.2 nM against wild-type LRRK2 and LRRK2[G2019S], respectively. HG-10-102-01 also inhibits MNK2 and MLK1, with IC50 values of 0.6 and 2.1 μM. HG-10-102-01 can be used for Parkinson's disease (PD) research[1][2].

• Target Antigen:

  LRRK2; MNK

• Type:

  Reference compound

• Related Pathways:

  Autophagy;MAPK/ERK Pathway

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/HG-10-102-01.html

• Smiles:

  COC1=CC(C(N2CCOCC2)=O)=CC=C1NC3=NC(NC)=C(Cl)C=N3

• Molecular Weight:

  377.83

• References & Citations:

  [1]Choi HG, et al. Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662.|[2]Wang M, et al. Synthesis of [11C]HG-10-102-01 as a new potential PET agent for imaging of LRRK2 enzyme in Parkinson's disease. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1351-1355.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  1351758-81-0