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HG-12-6

CAT: 0804-HY-123956Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123956Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation[1].
CAS Number
2222354-57-4
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hg-12-6.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(CN2CCNCC2)C(C(F)(F)F)=C1)C3=CC=CC(C4=CC=C5C(SC(NC(C6CC6)=O)=N5)=N4)=C3
Molecular Formula
C29H27F3N6O2S
Molecular Weight
580.62
References & Citations
[1]Wang L, et al. Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4) . J Biol Chem. 2019 Mar 22;294 (12) :4511-4519.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4

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