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O, p'-DDE

CAT: 0804-HY-121779-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121779-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
O, p'-DDE (2,4-Dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass, and in sediments from DDT manufacturing plants around the Huntsville Spring Branch-Indian Creek tributary system, where it becomes a persistent organic pollutant (POP) . o, p'-DDE inhibits the binding of estrogens to the rainbow trout estrogen receptor (rtER) with an IC50 value of 3.2 μM. o, p'-DDE also induces estradiol secretion from isolated granulosa and theca cells of porcine ovarian follicles in a concentration-dependent manner. o, p'-DDE treatment increases follicle degeneration and reduces testis size in Japanese medaka (O. latipes) [1].
CAS Number
3424-82-6
Product Name Alternative
2,4'-DDE; 2,4-Dichlorodiphenyldichloroethylene; 2,4'-DDE; o, p'-Dichlorodiphenyldichloroethylene
UNSPSC
12352005
Hazard Statement
H225-H301+H311+H331-H302-H351-H370-H410
Target
Insecticide
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/o-p-dde.html
Smiles
ClC1=CC=C(C=C1)/C(C2=CC=CC=C2Cl)=C(Cl)/Cl
Molecular Formula
C14H8Cl4
Molecular Weight
318.03
Precautions
P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P273-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P391-P403+P233-P403+P235-P405-P501
References & Citations
[1]Matthews, et al. Differential estrogen receptor binding of estrogenic substances: A species comparison. J. Steroid. Biochem. Mol. Biol. 74 (4), 223-234 (2000) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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