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HVH-2930

CAT: 0804-HY-161781-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161781-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HVH-2930 is an inhibitor for heat shock protein 90 (HSP90). HVH-2930 inhibits cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab (HY-P9907) resistant), with IC50 of 6.86 μM and 4.42 μM, through downregulation of HSP90 clients HER2, p-HER2, AKT, p-AKT, cyclin D1 and survivin. HVH-2930 exhibits antitumor efficacy in mouse models. HVH-2930 exhibits good pharmacokinetic characteristics in mice[1].
CAS Number
3034605-72-3
UNSPSC
12352005
Target
Akt; EGFR; HSP; Survivin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hvh-2930.html
Purity
96.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(OC)C(C=CC(C)(C)O2)=C2C=C1)NC3=CC4=C(C=C3)C(C)=NN4CCC5CCN(C)CC5
Molecular Formula
C29H36N4O3
Molecular Weight
488.62
References & Citations
[1]La M T, et al. Discovery of Indazole Inhibitors for Heat Shock Protein 90 as Anti-Cancer Agents[J]. European Journal of Medicinal Chemistry, 2024: 116620.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

5-methoxy-2,2-dimethyl-N-[3-methyl-1-[2-(1-methylpiperidin-4-yl)ethyl]indazol-6-yl]chromene-6-carboxamide
CAS Number3034605-72-3
PubChem CID171514416
IUPAC Name5-methoxy-2,2-dimethyl-N-[3-methyl-1-[2-(1-methylpiperidin-4-yl)ethyl]indazol-6-yl]chromene-6-carboxamide
Molecular FormulaC29H36N4O3
Molecular Weight488.6
XLogP4.8
Topological Polar Surface Area68.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity795
SMILES
CC1=NN(C2=C1C=CC(=C2)NC(=O)C3=C(C4=C(C=C3)OC(C=C4)(C)C)OC)CCC5CCN(CC5)C
InChI
InChI=1S/C29H36N4O3/c1-19-22-7-6-21(18-25(22)33(31-19)17-13-20-11-15-32(4)16-12-20)30-28(34)24-8-9-26-23(27(24)35-5)10-14-29(2,3)36-26/h6-10,14,18,20H,11-13,15-17H2,1-5H3,(H,30,34)
InChIKey
DBAWJYXZNCEOOW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-methoxy-2,2-dimethyl-N-[3-methyl-1-[2-(1-methylpiperidin-4-yl)ethyl]indazol-6-yl]chromene-6-carboxamide
CAS: 3034605-72-3
CID: 171514416
Formula: C29H36N4O3
MW: 488.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight488.6
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass488.27874102
Monoisotopic Mass488.27874102
Topological Polar Surface Area68.6 Ų
Heavy Atom Count36
Formal Charge0
Complexity795
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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