BAY-293

CAT: 0804-HY-114398-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114398-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1) . SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS[1].
CAS Number
[2244904-70-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BAY-293.html
Purity
98.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C=C(N=C(C)N=C2N[C@H](C)C3=CC(C4=C(CNC)C=CC=C4)=CS3)C2=C1
Molecular Formula
C25H28N4O2S
Molecular Weight
448.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Hillig RC, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116 (7) :2551-2560.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

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