Products for Research Use Only
RegisterLogin

HVH-2930

CAT: 0931-T88646-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T88646-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
3034605-72-3
Target
Survivin, EGFR, HSP, Akt
Related Pathways
PI3K/Akt/mTOR signaling, JAK/STAT signaling, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis, Metabolism
Bioactivity
HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90) . It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 μM and 4.42 μM, respectively. Additionally, HVH-2930 demonstrates antitumor efficacy in a mouse model and exhibits favorable pharmacokinetic properties in vivo.
Smiles
O=C(NC=1C=CC=2C(=NN(C2C1)CCC3CCN(C)CC3)C)C4=CC=C5OC(C=CC5=C4OC)(C)C
Molecular Formula
C29H36N4O3
Molecular Weight
488.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T24186-01J 2931
T22662-01Chromanol 293B
T83393-01293P-1
T27864-01LX-2931
T22510-01(-)-Chromanol 293B
T5418-01BAY-293
T19700-01IBC 293
T3348-01PIK-293
T27422-01GNE-293
T41214(S) -BAY-293

Alternative Products

CatalogName
HY-161781-01HVH-2930
136048DUSP8 (Dual Specificity Protein Phosphatase 8, Dual Specificity Protein Phosphatase hVH-5)
MBS6000260-01DUSP8 (Dual Specificity Protein Phosphatase 8, Dual Specificity Protein Phosphatase hVH-5, VH5)
MBS627559-01DUSP8, CT (Dual Specificity Protein Phosphatase 8, Dual Specificity Protein Phosphatase hVH-5, VH5)
D9840-30HDUSP8 (Dual Specificity Protein Phosphatase 8, Dual Specificity Protein Phosphatase hVH-5, VH5) discontinued
MBS6473209-01DUSP8, CT (Dual Specificity Protein Phosphatase 8, Dual Specificity Protein Phosphatase hVH-5, VH5) (PE)
MBS6473202-01DUSP8, CT (Dual Specificity Protein Phosphatase 8, Dual Specificity Protein Phosphatase hVH-5, VH5) (FITC)
MBS6473201-01DUSP8, CT (Dual Specificity Protein Phosphatase 8, Dual Specificity Protein Phosphatase hVH-5, VH5) (Biotin)
MBS6473200-01DUSP8, CT (Dual Specificity Protein Phosphatase 8, Dual Specificity Protein Phosphatase hVH-5, VH5) (APC)
MBS6473199-01DUSP8, CT (Dual Specificity Protein Phosphatase 8, Dual Specificity Protein Phosphatase hVH-5, VH5) (AP)

Popular Products