GNE-293

• Description :

  GNE-293 is a potent and selective PI3Kδ inhibitor (IC50 = 4.38 nM) . GNE-293 has favorable pharmacokinetic properties. GNE-293 can be used for research of asthma, rheumatoid arthritis, and other inflammatory disorders[1].

• UNSPSC :

  12352005

• Target :

  PI3K

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/gne-293.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)C1=NC(C=CC=C2)=C2N1C3=NC4=C(N=C(OC5CN(C6CCS(CC6)(=O)=O)C5)N4C)C(N7CCOCC7)=N3

• Molecular Formula :

  C28H36N8O4S

• Molecular Weight :

  580.70

• References & Citations :

  [1]Safina BS, et al. Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity. Bioorg Med Chem Lett. 2013 Sep 1;23 (17) :4953-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1354955-67-1]