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GNE-293

CAT: 0804-HY-12517Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12517Size:1 Each
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Description
GNE-293 is a potent and selective PI3Kδ inhibitor (IC50 = 4.38 nM) . GNE-293 has favorable pharmacokinetic properties. GNE-293 can be used for research of asthma, rheumatoid arthritis, and other inflammatory disorders[1].
CAS Number
1354955-67-1
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gne-293.html
Solubility
10 mM in DMSO
Smiles
CC(C)C1=NC(C=CC=C2)=C2N1C3=NC4=C(N=C(OC5CN(C6CCS(CC6)(=O)=O)C5)N4C)C(N7CCOCC7)=N3
Molecular Formula
C28H36N8O4S
Molecular Weight
580.70
References & Citations
[1]Safina BS, et al. Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity. Bioorg Med Chem Lett. 2013 Sep 1;23 (17) :4953-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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