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YM-44778

CAT: 0804-HY-120167Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120167Size:1 Each
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Description
YM-44778 is a neurokinin receptor antagonist. The pKi values for NK1, NK2 and NK3 are 8.08, 8.55 and 8.24, respectively. YM-44778 inhibits the increase of bladder pressure induced by substance [Sar9, Met (O2) 11] -P in anestheticized rats[1].
CAS Number
173941-74-7
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ym-44778.html
Smiles
O=C(C1=CC(OC)=C(C(OC)=C1)OC)N(C)CC(CCN2CCC3(NC(CC4=C3C=CC=C4)=O)CC2)C5=CC=C(C(Cl)=C5)Cl
Molecular Formula
C34H39Cl2N3O5
Molecular Weight
640.60
References & Citations
[1]Choppin A, et al. Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002;65 (2) :96-102.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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