Nortriptyline

Nortriptyline

• CAS Number: 72-69-5
• UNSPSC Description: Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3]. N
• Target Antigen: Apoptosis; Autophagy; Drug Metabolite
• Type: Natural Products
• Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease
• Field of Research: Cancer; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/nortriptyline.html
• Purity: 99.97
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13
• Molecular Weight: 263.384
• References & Citations: [1]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD): National Center for Biotechnology Information (US); March 23, 2017.|[2]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: Launched