Nortriptyline

CAT: 0804-HY-118620-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-118620-01Size:5 mg
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Description
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3]. N
CAS Number
[72-69-5]
Product Name Alternative
Desmethylamitriptyline; Desitriptilina
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Drug Metabolite
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nortriptyline.html
Purity
99.97
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13
Molecular Formula
C19H21N
Molecular Weight
263.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD) : National Center for Biotechnology Information (US) ; March 23, 2017.|[2]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Citation 01
EMBO Mol Med. 2025 Dec;17 (12) :3555-3585.|Cell Commun Signal. 2023 May 25;21 (1) :123.|J Exp Med. 2023 Mar 6;220 (3) :e20221316.

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