Nortriptyline

• Description :

  Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3]. N

• Product Name Alternative :

  Desmethylamitriptyline; Desitriptilina

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Autophagy; Drug Metabolite

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Autophagy; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/nortriptyline.html

• Purity :

  99.97

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13

• Molecular Formula :

  C19H21N

• Molecular Weight :

  263.38

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD) : National Center for Biotechnology Information (US) ; March 23, 2017.|[2]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Citation 01 :

  EMBO Mol Med. 2025 Dec;17 (12) :3555-3585.|Cell Commun Signal. 2023 May 25;21 (1) :123.|J Exp Med. 2023 Mar 6;220 (3) :e20221316.

• CAS Number :

  [72-69-5]