Products for Research Use Only
RegisterLogin

Nortriptyline (hydrochloride)

CAT: 0804-HY-B1417-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1417-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects[1][2][3].
CAS Number
894-71-3
Product Name Alternative
Desmethylamitriptyline (hydrochloride) ; Desitriptilina (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Autophagy; Drug Metabolite
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Nortriptyline-hydrochloride.html
Purity
99.98
Solubility
DMSO : 70 mg/mL (ultrasonic) |H2O : 7.14 mg/mL (ultrasonic)
Smiles
CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13.[H]Cl
Molecular Formula
C19H22ClN
Molecular Weight
299.85
Precautions
H302
References & Citations
[1]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US) ; 2012-2017 Mar 23.|[2]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Cell Commun Signal. 2023 May 25;21 (1) :123.|J Exp Med. 2023 Mar 6;220 (3) :e20221316.|EMBO Mol Med. 2025 Dec;17 (12) :3555-3585.

Related Products

CatalogName
HY-B1417S-01Nortriptyline-d3 (hydrochloride)
HY-144141S-01Nortriptyline impurity 3-d3 (hydrochloride)
HY-118620-01Nortriptyline
HY-118620R-01Nortriptyline (Standard)
HY-B0500BAlverine (hydrochloride)
HY-W714513VU0469650 (hydrochloride)
HY-W708286-01α-Pyrrolidinobutiothiophenone (hydrochloride)
HY-W492795Quifenadine (hydrochloride)
HY-W012179-01Phenylpiperazine (hydrochloride)
HY-Z6449-01Phenylephrone (hydrochloride)

Alternative Products

CatalogName
BUP15798-01Nortriptyline hydrochloride
C4077-100Nortriptyline (hydrochloride)
CS-O-06825Nortriptyline-d3 Hydrochloride

Popular Products