Nortriptyline (hydrochloride)
CAT:
804-HY-B1417-02
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Nortriptyline (hydrochloride)
- CAS Number: 894-71-3
- UNSPSC Description: Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects[1][2][3].
- Target Antigen: Apoptosis; Autophagy; Drug Metabolite
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/Nortriptyline-hydrochloride.html
- Purity: 99.98
- Solubility: DMSO : 70 mg/mL (ultrasonic)|H2O : 7.14 mg/mL (ultrasonic)
- Smiles: CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13.[H]Cl
- Molecular Weight: 299.845
- References & Citations: [1]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.|[2]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched