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Caspase 1 Activity Assay Kit (Colorimetric Method)

CAT: 0763-E-CK-A381-01Size: 20 AssaysDry Ice: NoHazardous: No
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CAT#:0763-E-CK-A381-01Size:20 Assays
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Detection Method
Colorimetric method
Assay Principle
Caspase 1, also known as Interkeukin 1β Conberting Enzyme (ICE), is the only caspase in the caspase family that can cleave IL-1β prefixes or IL-18 prefabrication. Caspase 11 can cleave 45 kD caspase 1 preparation to produce 20 kD and 10 kD fragments, which can form heterodimer and further form tetramer by two heterodimers. Caspase 1 regulates apoptosis by cleaving Bcl-XL and the associated immune response by cleaving cytokine precursors, or regulates pyroptosis by hydrolyzing Gastermin D (GSDMD) . This caspase 1 activity assay kit is based on caspase 1 that can catalyze the substrate AC-YVAD-pNA to generate yellow pNA (p-Nitroaniline) . The pNA has a strong absorption near 405 nm, The activity of caspase 1 can be calculated by determining the absorbance at 405 nm.
Sample Type
Cell and tissue samples
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at -20°C for 12 months with shading light.
Citation 01
https://www.sciencedirect.com/science/article/pii/S0925521424005106
Citation 02
https://www.sciencedirect.com/science/article/pii/S0024320524005563
Citation 03
https://www.sciencedirect.com/science/article/pii/S1567576924022380
Citation 04
https://www.sciencedirect.com/science/article/pii/S0378874124016118
Citation 05
https://www.sciencedirect.com/science/article/pii/S1567576925007416
Citation 06
https://www.nature.com/articles/s41598-024-84959-z
Citation 07
https://www.sciencedirect.com/science/article/pii/S1043466625000225
Citation 08
https://www.ingentaconnect.com/content/ben/acamc/2023/00000023/00000001/art00012
Citation 09
https://www.frontiersin.org/articles/10.3389/frph.2023.1204728/full
Citation 10
https://www.sciencedirect.com/science/article/pii/S0928468017301451
Detection Instrument
Spectrophotometer; Microplate reader

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