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(R) -Bicalutamide

CAT: 0804-HY-108250-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108250-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Bicalutamide is the (R) -enantiomer of Bicalutamide. (R) -Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R) -Bicalutamide is widely used for the research of prostate cancer[1][2].
CAS Number
113299-40-4
UNSPSC
12352005
Hazard Statement
H302
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-bicalutamide.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)CS(=O)(C2=CC=C(F)C=C2)=O
Molecular Formula
C18H14F4N2O4S
Molecular Weight
430.37
Precautions
H302
References & Citations
[1]Hongli Liu, et al. Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation. J Comput Aided Mol Des. 2016 Dec;30 (12) :1189-1200.|[2]Sara Pignatta, et al. Prolonged exposure to (R) -bicalutamide generates a LNCaP subclone with alteration of mitochondrial genome. Mol Cell Endocrinol. 2014 Jan 25;382 (1) :314-324.|[3]Anna Tesei, et al. Effect of Small Molecules Modulating Androgen Receptor (SARMs) in Human Prostate Cancer Models. PLoS One. 2013; 8 (5) : e62657.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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