(R) -Bicalutamide

• Description:

  (R) -Bicalutamide is the (R) -enantiomer of Bicalutamide (HY-14249) . (R) -Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R) -Bicalutamide is widely used for the research of prostate cancer[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Androgen Receptor

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/r-bicalutamide.html

• Purity:

  99.95

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (NC1=CC=C (C#N) C (C (F) (F) F) =C1) [C@@] (C) (O) CS (=O) (C2=CC=C (F) C=C2) =O

• Molecular Formula:

  C18H14F4N2O4S

• Molecular Weight:

  430.37

• Precautions:

  H302

• References & Citations:

  [1]Hongli Liu, et al. Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation. J Comput Aided Mol Des. 2016 Dec;30 (12) :1189-1200.|[2]Sara Pignatta, et al. Prolonged exposure to (R) -bicalutamide generates a LNCaP subclone with alteration of mitochondrial genome. Mol Cell Endocrinol. 2014 Jan 25;382 (1) :314-324.|[3]Anna Tesei, et al. Effect of Small Molecules Modulating Androgen Receptor (SARMs) in Human Prostate Cancer Models. PLoS One. 2013; 8 (5) : e62657.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  113299-40-4