(R) -Bicalutamide

• Description :

  (R) -Bicalutamide is the (R) -enantiomer of Bicalutamide (HY-14249) . (R) -Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R) -Bicalutamide is widely used for the research of prostate cancer[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Androgen Receptor

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/r-bicalutamide.html

• Purity :

  99.95

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)CS(=O)(C2=CC=C(F)C=C2)=O

• Molecular Formula :

  C18H14F4N2O4S

• Molecular Weight :

  430.37

• Precautions :

  H302

• References & Citations :

  [1]Hongli Liu, et al. Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation. J Comput Aided Mol Des. 2016 Dec;30 (12) :1189-1200.|[2]Sara Pignatta, et al. Prolonged exposure to (R) -bicalutamide generates a LNCaP subclone with alteration of mitochondrial genome. Mol Cell Endocrinol. 2014 Jan 25;382 (1) :314-324.|[3]Anna Tesei, et al. Effect of Small Molecules Modulating Androgen Receptor (SARMs) in Human Prostate Cancer Models. PLoS One. 2013; 8 (5) : e62657.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [113299-40-4]