(R,R)-THC

(R,R)-THC

• CAS Number: 221368-54-3
• UNSPSC Description: (R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1].
• Target Antigen: Estrogen Receptor/ERR
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/r-r-thc.html
• Purity: 99.0
• Solubility: 10 mM in DMSO
• Smiles: OC(C=C1C[C@H]2CC)=CC=C1C3=C2C4=C(C=C(O)C=C4)C[C@H]3CC
• Molecular Weight: 320.42
• References & Citations: [1]Sun J, et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999;140(2):800-804.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported