(R, R) -THC

CAT: 0804-HY-103451Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103451Size:5 mg
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Description
(R, R) -THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R, R) -THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1].
CAS Number
[221368-54-3]
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/r-r-thc.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
OC(C=C1C[C@H]2CC)=CC=C1C3=C2C4=C(C=C(O)C=C4)C[C@H]3CC
Molecular Formula
C22H24O2
Molecular Weight
320.42
References & Citations
[1]Sun J, et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999;140 (2) :800-804.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ

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