PSMC6 Rabbit Polyclonal Antibody

PSMC6 Rabbit Polyclonal Antibody

• Description: 26S protease regulatory subunit S10B, also known as 26S proteasome AAA-ATPase subunit Rpt4, is an enzyme that in humans is encoded by the PSMC6 gene. As the degradation machinery that is responsible for ~70% of intracellular proteolysis, proteasome complex (26S proteasome) plays a critical roles in maintaining the homeostasis of cellular proteome. Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; in parallel, some key regulatory proteins fulfill their biological functions via selective degradation; furthermore, proteins are digested into peptides for MHC class I antigen presentation. To meet such complicated demands in biological process via spatial and temporal proteolysis, protein substrates have to be recognized, recruited, and eventually hydrolyzed in a well controlled fashion. Thus, 19S regulatory particle pertains a series of important capabilities to address these functional challenges. To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special degradative tag, the ubiquitinylation. It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S particles, as well as to cause confirmation changes of alpha subunit C-terminals that form the substate entrance of 20S complex.
• Product Name Alternative: 26S protease regulatory subunit 10B antibody 26S protease regulatory subunit S10B antibody 26S proteasome AAA-ATPase subunit RPT4 antibody CADP44 antibody P44 antibody Proteasome 26S subunit ATPase 6 antibody Proteasome subunit p42 antibody PRS10_HUMAN antibody PSMC6 antibody Rpt4 antibody SUG2 antibody
• Abbreviation: PSMC6
• CAS Number: 9007-83-4
• Swiss Prot: P62333 Human, P62334 Mouse,
• Cellular Locus: Nucleus, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human PSMC6 aa 1-200 / 389.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: HepG2 cell lysate, PC-12 cell lysate, rat kidney tissue lysate, 293T cell lysate, SH-SY5Y cell lysate, mouse heart tissue lysate, mouse kidney tissue lysate, SH-SY5Y, rat hippocampus tissue, rat brain tissue, human kidney clear cell carcinoma tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000;IF-Cell: 1:100;IHC-P: 1:1,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 44 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No