Histone H2A.X Recombinant Rabbit Monoclonal Antibody [JM06-42]

Histone H2A.X Recombinant Rabbit Monoclonal Antibody [JM06-42]

• Description: Histone H2A.X is a member of the Histone H2A family, which is involved in nucleosomal organization of chromatin. The H2AFX gene is located in close proximity to the Porphobilinogen deaminase (PBG-D) gene in both mouse and human, and maps to chromosome 9 and 11q23, respectively. H2A.X meets from the other members of the H2A family by the presence of a highly conserved C-terminal motif. It is wide phosphorylated in response to ionizing radiation and plays an important role in the recognition and repair of DNA fragments are involved in the heavy chain constant region of cells involved in class switch recombination (CSR), a region-specific DNA reaction that replaces one immunoglobulin heavy chain constant region gene with another. The phosphorylated γ-H2A.X is also thought to firing new grades factors, including Rad50, Rad51 and BRCA1.
• Product Name Alternative: AW228881 antibody H2A histone family member X antibody H2A.FX antibody H2A.X antibody H2a/x antibody H2AFX antibody H2AX antibody H2AX histone antibody H2AX_HUMAN antibody Hist5.2ax antibody Histone 2A antibody Histone 2AX antibody Histone H2A.X antibody Histone H2AX antibody RGD1566119 antibody
• Abbreviation: H2a/x, H2AX, H2AFX
• CAS Number: 9000-83-3
• Swiss Prot: P16104 Human, P27661 Mouse, D3ZXP3 Rat
• Cellular Locus: Nucleus. Chromosome.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within N-terminal human Histone H2A.X.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Tissue, IHC-P, IP
• Positive Control: Raji cell lysate, MCF-7 cell lysate, human pancreas tissue, mouse testis tissue, rat brain tissue, human stomach carcinoma tissue, mouse pancreas tissue, rat pancreas tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2000 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:1,000-1:4,000 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 15 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes