Histone H2A.x Rabbit Polyclonal Antibody

Histone H2A.x Rabbit Polyclonal Antibody

• Description: Histone H2A.X is a member of the Histone H2A family, which is involved in nucleosomal organization of chromatin. The H2AFX gene is located in close proximity to the Porphobilinogen deaminase (PBG-D) gene in both mouse and human, and maps to chromosome 9 and 11q23, respectively. H2A.X differs from the other members of the H2A family by the presence of a highly conserved C-terminal motif. It is rapidly phosphorylated in response to ionizing radiation and plays an important role in the recognition and repair of DNA double stranded breaks. The phosphorylated form of H2A.X, designated γ-H2A.X, forms nuclear foci at the heavy chain constant region of cells involved in class switch recombination (CSR), a region-specific DNA reaction that replaces one immunoglobulin heavy chain constant region gene with another. The phosphorylated γ-H2A.X is also thought to initiate subsequent repair factors, including Rad50, Rad51 and BRCA1.
• Product Name Alternative: AW228881 antibody H2A histone family member X antibody H2A.FX antibody H2A.X antibody H2a/x antibody H2AFX antibody H2AX antibody H2AX histone antibody H2AX_HUMAN antibody Hist5.2ax antibody Histone 2A antibody Histone 2AX antibody Histone H2A.X antibody Histone H2AX antibody RGD1566119 antibody
• Abbreviation: Histone H2AX,H2a/x,Histone H2A.X,H2AFX,
• CAS Number: 9007-83-4
• Swiss Prot: P16104 Human, P27661 Mouse
• Cellular Locus: Nucleus
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Histone H2AX aa 1-50 / 143.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P, IF-Cell, IF-Tissue, FC
• Positive Control: MCF-7 cell lysates, SHSY5Y, Rat testicular tissue, human lung cancer tissue, human liver tissue, mouse fallopian tube tissue.
• Concentration: 1mg/mL
• Dilution: WB:1:500-1:1000;IHC-P:1:100-1:500;IF-Cell:1:100-1:500;IF-Tissue:1:100-1:500;FC:1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 15 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No