Von Willebrand Factor Recombinant Rabbit Monoclonal Antibody [JJ09-34]

Von Willebrand Factor Recombinant Rabbit Monoclonal Antibody [JJ09-34]

• Description: Von Willebrand disease is a congenital bleeding disorder caused by defects in the von Willebrand factor protein (VWF). VWF is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets, and it is involved in the coagulation of blood at injury sites. VWF acts as a carrier protein for Factor VIII, a cofactor required for coagulation, and it promotes platelet adhesion and aggregation. Several factors are known to stimulate the binding of VWF to platelets, including glycoprotein 1b, ristocetin, botrocetin, collagen, sulphatides and heparin. Of the several domains contained within VWF, the A1, A2 and A3 domains have been shown to mediate this activation. VWF is thought to undergo a variety of posttranslational modifications that influence the affinity and availability for Factor VII, including cleavage of the propeptide and formation of N-terminal intersubunit disulfide bonds.
• Product Name Alternative: Coagulation factor VIII antibody Coagulation factor VIII VWF antibody F8VWF antibody Factor VIII related antigen antibody von Willebrand antigen 2 antibody von Willebrand antigen II antibody Von Willebrand disease antibody VWD antibody vWF antibody VWF_HUMAN antibody
• Abbreviation: vWF
• CAS Number: 9000-83-3
• Swiss Prot: P04275 Human, Q8CIZ8 Mouse
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant protein within Human Von Willebrand Factor aa 1170-1320 / 2813.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: BEnd.3 cell lysate, human lung tissue lysate, mouse lung tissue lysate, mouse liver tissue lysate, human tonsil tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:5,000 ;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 309 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes