Factor X Recombinant Rabbit Monoclonal Antibody [JE32-83]

Factor X Recombinant Rabbit Monoclonal Antibody [JE32-83]

• Description: Coagulation factor X (EC 3.4.21.6), or Stuart factor, is an enzyme of the coagulation cascade, encoded in humans by F10 gene. It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis. Factor X is activated, by hydrolysis, into factor Xa by both factor IX with its cofactor, factor VIII in a complex known as intrinsic pathway; and factor VII with its cofactor, tissue factor in a complex known as extrinsic pathway. It is therefore the first member of the final common pathway or thrombin pathway. It acts by cleaving prothrombin in two places (an Arg-Thr and then an Arg-Ile bond), which yields the active thrombin. This process is optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex. Factor Xa is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z, while it does not require protein Z for inactivation of factor XI. Defects in protein Z lead to increased factor Xa activity and a propensity for thrombosis. The half life of factor X is 40–45 hours.
• Product Name Alternative: Activated factor Xa heavy chain antibody Coagulation factor X antibody F10 antibody FA10_HUMAN antibody factor Xa antibody FX antibody FXA antibody Prothrombinase antibody Stuart factor antibody Stuart Prower factor antibody Stuart-Prower factor antibody
• Abbreviation: F10
• CAS Number: 9000-83-3
• Swiss Prot: P00742 Human, O88947 Mouse, Q63207 Rat
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein.
• Isotype: IgG
• Clone: JE32-83
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Human plasma lysate, Human serum lysate, Mouse plasma lysate, Rat plasma lysate, Human liver tissue lysate, human liver tissue, mouse liver tissue, rat liver tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IHC-P: 1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 55 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes