Factor H Recombinant Rabbit Monoclonal Antibody [JA52-13]

Factor H Recombinant Rabbit Monoclonal Antibody [JA52-13]

• Description: The Factor H gene family is a multidomain, multifunctional protein family whose individual members are defined by conserved structural elements, which display diverse yet often overlapping functions. These proteins share a common structural motif, the short consensus repeat (SCR), which is structurally conserved among related genes and between phylogenetically divergent species. The human complement Factor H (FH, CFH, HUS, b-1H) gene encodes a 1213 amino acid serum glycoprotein which is arranged into 20 SCRs, each approximately 60 amino acids long, and an 18-residue leader sequence. Factor H controls the function of the alternative complement pathway and acts as a cofactor with Factor I (C3b inactivator). In addition, Factor H has functional activity outside of the complement system, where it can bind to the cellular integrin receptor (CD11b/CD18), interact with cell surface glycosaminoglycans and associate with the surface of certain pathogenic microorganisms. Deficiencies in Factor H is a common characteristic of acute renal disease.
• Product Name Alternative: adrenomedullin binding protein antibody age related maculopathy susceptibility 1 antibody AHUS 1 antibody AHUS1 antibody AMBP 1 antibody AMBP1 antibody ARMD 4 antibody ARMD4 antibody ARMS 1 antibody ARMS1 antibody beta 1 H globulin antibody beta 1H antibody beta1H antibody CFAH_HUMAN antibody CFH antibody CFHL 3 antibody CFHL3 antibody Complement factor H antibody complement factor H, isoform b antibody Factor H antibody factor H like 1 antibody FH antibody FHL 1 antibody FHL1 antibody H factor 1 (complement) antibody H factor 1 antibody H factor 2 (complement) antibody HF 1 antibody HF 2 antibody HF antibody HF1 antibody HF2 antibody HUS antibody MGC88246 antibody
• Abbreviation: CFH, HF, HF1, HF2
• CAS Number: 9000-83-3
• Swiss Prot: P08603 Human
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Factor H aa 131-180 / 1231.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: Human kidney tissue lysates, Hela, HepG2, human liver tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 140 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes