Human Von Willebrand Factor Recombinant Rabbit Monoclonal Antibody [PSH09-03] - BSA and Azide free (Capture)

Human Von Willebrand Factor Recombinant Rabbit Monoclonal Antibody [PSH09-03] - BSA and Azide free (Capture)

• Description: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in altered platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet-dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.
• Product Name Alternative: Coagulation factor VIII antibody Coagulation factor VIII VWF antibody F8VWF antibody Factor VIII related antigen antibody von Willebrand antigen 2 antibody von Willebrand antigen II antibody Von Willebrand disease antibody Von Willebrand factor precursor antibody VWD antibody vWF antibody VWF_HUMAN antibody
• Abbreviation: von Willebrand factor vWF F8VWF
• CAS Number: 9000-83-3
• Swiss Prot: P04275 Human
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within human von Willebrand factor protein aa 764-1263.
• Isotype: IgG
• Clone: PSH09-03
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Cap)
• Positive Control: Recombinant human von Willebrand factor protein.
• Concentration: 1 mg/mL
• Dilution: ELISA (Cap): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH09-04] to Human Von Willebrand Factor antibody (Detector) (HA723059) and Recombinant Human Von Willebrand Factor protein as the standard. The reference range value is 370-30,000 pg/ml.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4).
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes