Steroidogenic Factor 1 Recombinant Rabbit Monoclonal Antibody [JE33-89]

Steroidogenic Factor 1 Recombinant Rabbit Monoclonal Antibody [JE33-89]

• Description: The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling the activity of genes related to the reproductive glands or gonads and adrenal glands. This protein is encoded by the NR5A1 gene, a member of the nuclear receptor subfamily, located on the long arm of chromosome 9 at position 33.3. It was originally identified as a regulator of genes encoding cytochrome P450 steroid hydroxylases, however, further roles in endocrine function have since been discovered. SF-1 is a critical regulator of reproduction, regulating the transcription of key genes involved in sexual development and reproduction, most notably StAR and P450SCC. It can form a transcriptional complex with TDF to up-regulate transcription of the Sox9 gene. Its targets include genes at every level of the hypothalamic-pituitary-gonadal axis, as well as many genes involved in gonadal and adrenal steroidogenesis. SF-1 has been identified as a transcriptional regulator for an array of different genes related to sex determination and differentiation, reproduction, and metabolism via binding to their promoters. For example, SF-1 controls expression of Amh gene in Sertoli cells, whereby the presence or absence of the gene product affects development of Müllerian structures. Increased AMH protein levels leads to regression of such structures. Leydig cells express SF-1 to regulate transcription of steroidogenesis and testosterone biosynthesis genes causing virilization in males.
• Product Name Alternative: AD4BP antibody Adrenal 4 binding protein antibody Adrenal 4-binding protein antibody ELP antibody FTZ 1 antibody FTZ1 antibody FTZF 1 antibody FTZF1 antibody Fushi tarazu factor (Drosophila) homolog 1 antibody Fushi tarazu factor homolog 1 antibody hSF 1 antibody NR5A1 antibody Nuclear receptor AdBP4 antibody Nuclear receptor subfamily 5 group A member 1 antibody POF7 antibody SF 1 antibody SF-1 antibody SF1 antibody SPGF8 antibody SRXY3 antibody Steroid hormone receptor Ad4BP antibody Steroidogenic factor 1 antibody Steroidogenic factor 1 nuclear receptor antibody STF 1 antibody STF-1 antibody STF1 antibody STF1_HUMAN antibody
• Abbreviation: NR5A1, AD4BP, FTZF1, SF1
• CAS Number: 9000-83-3
• Swiss Prot: Q13285 Human, P33242 Mouse, P50569 Rat
• Cellular Locus: Nucleus.
• Host: Rabbit
• Species Reactivity: Mouse, Rat, Human
• Immunogen: Recombinant protein within Human Steroidogenic Factor 1 aa 312-461 / 461.
• Isotype: IgG
• Clone: JE33-89
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB
• Positive Control: Mouse spleen tissue lysate, rat ovary tissue lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 52 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes