Factor XIIIa Recombinant Rabbit Monoclonal Antibody [PD00-08]

Factor XIIIa Recombinant Rabbit Monoclonal Antibody [PD00-08]

• Description: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti- Factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases +), dermatofibrosarcoma protuberans (-/+) and desmoplastic malignant melanoma (-). Anti-factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma.
• Product Name Alternative: bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody Coagulation factor XIII A chain antibody Coagulation factor XIII A1 polypeptide antibody Coagulation factor XIII A1 subunit antibody Coagulation factor XIII, A polypeptide antibody Coagulation factor XIIIa antibody F13A antibody F13A_HUMAN antibody F13a1 antibody Factor XIIIA antibody Fibrin stabilizing factor, A subunit antibody Fibrinoligase antibody FSF, A subunit antibody Protein glutamine gamma glutamyltransferase A chain antibody Protein-glutamine gamma-glutamyltransferase A chain antibody TGase antibody Transglutaminase A chain antibody Transglutaminase, plasma antibody Transglutaminase. plasma antibody
• Abbreviation: F13A1
• CAS Number: 9000-83-3
• Swiss Prot: P00488 Human
• Cellular Locus: Secreted, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Factor XIIIa C terminal.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Human placenta tissue lysates, human lymph nodes tissue, human placenta tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500 ;IHC-P: 1:1,000-1:2,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 83 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes