Cdk6 Recombinant Rabbit Monoclonal Antibody [SD20-50]

Cdk6 Recombinant Rabbit Monoclonal Antibody [SD20-50]

• Description: Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene.[5][6] It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins.The protein encoded by this gene is a member of the cyclin-dependent kinase, (CDK) family, which includes CDK4. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression in the point of regulation named R or restriction point. This kinase is a catalytic subunit of the protein kinase complex, important for the G1 phase progression and G1/S transition of the cell cycle and the complex is composed also by an activating sub-unit; the cyclin D.The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors.This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor Retinoblastoma protein making CDK6 an important protein in cancer development.
• Product Name Alternative: CDK 6 antibody CDK6 antibody CDK6_HUMAN antibody Cell division protein kinase 6 antibody Crk 2 antibody Crk2 antibody Cyclin dependent kinase 6 antibody Cyclin-dependent kinase 6 antibody MGC59692 antibody p40 antibody PLSTIRE antibody Serine/threonine protein kinase PLSTIRE antibody Serine/threonine-protein kinase PLSTIRE antibody STQTL11 antibody
• Abbreviation: CDK6
• CAS Number: 9000-83-3
• Swiss Prot: Q00534 Human
• Cellular Locus: Cytoplasm, Nucleus, Cell projection.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Cdk6 aa 277-326 / 326.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IF-Cell, IF-Tissue, IHC-P, FC, WB
• Positive Control: K562 cell lysate, Hela cell lysate, Hela, SW480, 293, human colon carcinoma tissue, human tonsil tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 37 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes