CDK6 Rabbit Polyclonal Antibody

• Description :

  CDK6 protein contains a catalytic core composed of a serine/threonine domain.This protein also contains an ATP-binding pocket, inhibitory and activating phosphorylation sites, a PSTAIRE-like cyclin-binding domain and an activating T-loop motif. CDK6 is involved in a positive feedback loop that activates transcription factors through a reaction cascade. CDK6 is important for the control of G1 to S phase transition. However, in recent years, new evidence proved that the presence of CDK6 is not essential for proliferation in every cell type, the cell cycle has a complex circuitry of regulation and the role of CDK6 might be more important in certain cell types than in others, where CDK4 or CDK2 can act as protein kinases compensating its role.

• CAS Number :

  9007-83-4

• Product Name Alternative :

  CDK 6 antibody CDK6 antibody CDK6_HUMAN antibody Cell division protein kinase 6 antibody Crk 2 antibody Crk2 antibody Cyclin dependent kinase 6 antibody Cyclin-dependent kinase 6 antibody MGC59692 antibody p40 antibody PLSTIRE antibody Serine/threonine protein kinase PLSTIRE antibody Serine/threonine-protein kinase PLSTIRE antibody STQTL11 antibody

• Abbreviation :

  CDK6

• Swiss Prot :

  Q00534 Human, Q64261 Mouse,

• Cellular Locus :

  Cytoplasm, nucleus, Cell projection, Cytoskeleton.

• Host :

  Rabbit

• Species Reactivity :

  Human, Mouse, Rat, Monkey

• Immunogen :

  Synthetic peptide within residues of CDK6 aa 267-326 / 326.

• Isotype :

  IgG

• Conjugation :

  Non-conjugated

• Type :

  Rabbit polyclonal Antibody

• Applications :

  WB, IF-Cell, IHC-P

• Positive Control :

  HeLa cell lysate, SK-OV-3 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, K562 cell lysate, COS-1 cell lysate, Hela, HepG2, human lung cancer tissue, mouse thymus tissue, rat thymus tissue.

• Concentration :

  1 mg/mL

• Dilution :

  WB: 1:1,000-1:2,000 ;IF-Cell: 1:200 ;IHC-P: 1:200

• Purity :

  Immunogen affinity purified.

• Form :

  Liquid

• Buffer :

  1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight :

  Predicted band size: 37 kDa

• Storage Conditions :

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody :

  No