CDK6 Recombinant Rabbit mAb

• Background :

  The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]

• Structure Composition :

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative :

  MCPH12; PLSTIRE

• Swiss Prot :

  Q00534

• Reactivity :

  Human

• Immunogen :

  A synthetic peptide of human Cdk6

• Conjugation :

  Unconjugated

• Applications :

  WB, IHC, ICC/IF, FC

• Purity :

  Affinity Purification

• Modification :

  Unmodification

• Molecular Weight :

  37 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  IgG

• Applications Notes :

  Western blot detection of CDK6 in K562, Hela cell lysates using CDK6 antibody (1:1000 diluted) .

• Host or Source :

  Rabbit

• CAS Number :

  9000-83-3