TrkB Recombinant Rabbit Monoclonal Antibody [JE58-22]

TrkB Recombinant Rabbit Monoclonal Antibody [JE58-22]

• Description: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
• Product Name Alternative: AI848316 antibody BDNF tropomyosine receptor kinase B antibody BDNF/NT 3 growth factors receptor antibody BDNF/NT-3 growth factors receptor antibody Brain derived neurotrophic factor receptor antibody C030027L06Rik antibody EC 2.7.10.1 antibody GP145 TrkB antibody GP145-TrkB antibody GP145-TrkB/GP95-TrkB antibody GP95 TrkB antibody Neurotrophic receptor tyrosine kinase 2 antibody Neurotrophic tyrosine kinase receptor type 2 antibody Neurotrophin receptor tyrosine kinase type 2 antibody NTRK 2 antibody Ntrk2 antibody NTRK2_HUMAN antibody Obesity, hyperphagia, and developmental delay, included antibody RATTRKB1 antibody Tkrb antibody Trk B antibody Trk-B antibody TRKB antibody TrkB tyrosine kinase antibody TRKB1 antibody Tropomyosin related kinase B antibody tyrosine kinase receptor B antibody Tyrosine receptor kinase B antibody
• Abbreviation: Ntrk2
• CAS Number: 9000-83-3
• Swiss Prot: P15209 Mouse, Q63604 Rat
• Cellular Locus: Cell membrane, Endosome membrane, Early endosome membrane, axon, dendrite, perinuclear region, postsynaptic density.
• Host: Rabbit
• Species Reactivity: Mouse, Rat
• Immunogen: Recombinant protein within human TrkB aa 100-450/822.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Mouse brain tissue lysate, Rat brain tissue lysate, mouse brain tissue, rat brain tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IHC-P: 1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 92 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes