MMP-2 Recombinant Rabbit Monoclonal Antibody [SI15-04]

MMP-2 Recombinant Rabbit Monoclonal Antibody [SI15-04]

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Activation of MMP-2 requires proteolytic processing. A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP 2 from the extracellular milieu to the cell surface. Activation then requires an active molecule of MT1-MMP and auto catalytic cleavage. Clustering of integrin chains promotes activation of MMP-2. Another factor that will support the activation of MMP-2 is cell-cell clustering. A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2.
• Product Name Alternative: 72 kDa gelatinase antibody 72kD type IV collagenase antibody CLG 4 antibody CLG 4A antibody CLG4 antibody CLG4A antibody Collagenase Type 4 alpha antibody Collagenase type IV A antibody Gelatinase A antibody Gelatinase alpha antibody Gelatinase neutrophil antibody Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase antibody Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) antibody Matrix Metalloproteinase 2 antibody Matrix metalloproteinase II antibody Matrix metalloproteinase-2 antibody MMP 2 antibody MMP II antibody MMP-2 antibody MMP2 antibody MMP2_HUMAN antibody MONA antibody Neutrophil gelatinase antibody PEX antibody TBE 1 antibody TBE-1 antibody
• Abbreviation: MMP-2
• CAS Number: 9000-83-3
• Swiss Prot: P08253 Human, P33434 Mouse, P33436 Rat
• Cellular Locus: Cytoplasm, Nucleus, Membrane, Mitochondrion, Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human MMP2 aa 101-150 / 660.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: U-87 MG cell lysate, L6 cell lysate, mouse liver tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 74 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes