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GABRA5 Rabbit Polyclonal Antibody

CAT: 0992-ER1902-82Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1902-82Size:100 µL
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Description
Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. Recent research has produced several ligands which are moderately selective for GABAA receptors containing the α5 subunit. These have proved to be useful in investigating some of the side effects of benzodiazepine and nonbenzodiazepine drugs, particularly the effects on learning and memory such as anterograde amnesia. Inverse agonists at this subunit have nootropic effects and may be useful for the treatment of cognitive disorders such as Alzheimer's disease.
CAS Number
9007-83-4
Product Name Alternative
GAA 5 antibody GAA5 antibody GABA (A) receptor subunit alpha-5 antibody GABRA 5 antibody Gabra5 antibody Gamma aminobutyric acid GABA A receptor alpha 5 antibody Gamma aminobutyric acid GABA A receptor alpha 5 precursor antibody Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor antibody Gamma-aminobutyric acid receptor subunit alpha-5 antibody GBRA5_HUMAN antibody GC138184 antibody
Abbreviation
Gabra5
Swiss Prot
P31644 Human, P19969 Rat, Q8BHJ7 Mouse
Cellular Locus
Postsynaptic cell membrane, cell membrane.
Host
Rabbit
Species Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide within mouse GABRA5 aa 346-395 / 463.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Tissue, IHC-P, FC
Positive Control
Rat brain tissue lysates, rat brain tissue, mouse brain tissue, A549.
Concentration
1 mg/mL
Dilution
WB:1:500-1:1,000 ;IF-Tissue:1:50-1:100 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size 52 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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