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GABRB1 Rabbit Polyclonal Antibody

CAT: 0992-ER1901-66Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1901-66Size:100 µL
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Description
Gamma-aminobutyric acid receptor subunit beta-1 is a protein that in humans is encoded by the GABRB1 gene. Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. The gamma-aminobutyric acid A receptor (GABAA receptor) is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABAA receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. Mice bearing mutant copies of this gene have been shown to be vulnerable to binge drinking of alcohol. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
CAS Number
9007-83-4
Product Name Alternative
AW061132 antibody B230208N19Rik antibody GABA (A) receptor beta 1 antibody GABA (A) receptor subunit beta-1 antibody GABA-A receptor, beta-1 polypeptide antibody Gabrb-1 antibody GABRB1 antibody Gamma aminobutyric acid (GABA) A receptor beta 1 antibody Gamma Aminobutyric Acid A Receptor Beta 1 antibody Gamma Aminobutyric Acid Receptor , beta-1 antibody Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 antibody Gamma-aminobutyric acid receptor subunit beta-1 antibody GARB1 antibody GBRB1_HUMAN antibody
Abbreviation
GABRB1
Swiss Prot
P18505 Human, P50571 Mouse, P15431 Rat
Cellular Locus
Postsynaptic cell membrane, cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human GABRB1 aa 327-376 / 474.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Rat brain tissue lysates, 293T, LOVO, rat kidney tissue, human skin tissue, human breast tissue, human breast carcinoma tissue, human kidney tissue, mouse kidney tissue, mouse heart tissue, SH-SY5Y.
Concentration
1 mg/mL
Dilution
WB:1:500-1:2,000 ;IF-Cell:1:50-1:200 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size 54 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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