GABRA5 Recombinant Rabbit Monoclonal Antibody [JB34-19]

• Description:

  Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. Recent research has produced several ligands which are moderately selective for GABAA receptors containing the α5 subunit. These have proved to be useful in investigating some of the side effects of benzodiazepine and nonbenzodiazepine drugs, particularly the effects on learning and memory such as anterograde amnesia. Inverse agonists at this subunit have nootropic effects and may be useful for the treatment of cognitive disorders such as Alzheimer's disease.

• Product Name Alternative:

  GAA 5 antibody GAA5 antibody GABA (A) receptor subunit alpha-5 antibody GABRA 5 antibody Gabra5 antibody Gamma aminobutyric acid GABA A receptor alpha 5 antibody Gamma aminobutyric acid GABA A receptor alpha 5 precursor antibody Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor antibody Gamma-aminobutyric acid receptor subunit alpha-5 antibody GBRA5_HUMAN antibody GC138184 antibody

• Abbreviation:

  Gamma-aminobutyric acid receptor subunit alpha-5, GABA (A) receptor subunit alpha-5, GABAAR subunit alpha-5, GABRA5

• CAS Number:

  9000-83-3

• Swiss Prot:

  P31644 Human, Q8BHJ7 Mouse, P19969 Rat

• Cellular Locus:

  Postsynaptic cell membrane, Cell membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within Human GABRA5 aa 1-240 / 462.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IF-Tissue, IHC-P

• Positive Control:

  A549 cell lysate, Neuro-2a cell lysate, C6 cell lysate, Mouse brain tissue lysate, mouse brain tissue, rat brain tissue, mouse cerebellum tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:2,000 ;IF-Tissue: 1:500 ;IHC-P: 1:1,000

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 52 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  Yes