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GABRB3 Rabbit Polyclonal Antibody

CAT: 0992-HA500090Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500090Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity. The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. Plays an important role in somatosensation and in the production of antinociception.
CAS Number
9007-83-4
Product Name Alternative
ECA5 antibody GABA alpha receptor beta-2 subunit antibody GABA (A) receptor subunit beta-3 antibody GABAA receptor beta 3 subunit antibody GABAA receptor subunit beta 3 antibody GABR B3 antibody Gabrb3 antibody Gamma aminobutyric acid (GABA) A receptor beta 3 antibody Gamma aminobutyric acid receptor subunit beta 3 antibody Gamma-aminobutyric acid receptor subunit beta-3 antibody GBRB3_HUMAN antibody MGC9051 antibody
Abbreviation
Gamma-aminobutyric acid receptor subunit beta-3, GABA (A) receptor subunit beta-3, GABAAR subunit beta-3, GABRB3
Swiss Prot
P28472 Human, P63080 Mouse, P63079 Rat
Cellular Locus
Plasma membrane, Cell membrane, Cytoplasmic vesicle membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within human GABRB3 aa 400-443 (Cytoplasmic domain).
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Rat brain tissue lysate, rat cerebellum tissue lysate, mouse brain tissue lysate, mouse cerebellum tissue lysate, HepG2 cell lysate, 293 cell lysate, rat brain tissue, human lung tissue, mouse brain tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:100-1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 54 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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