Z-IETD-R110

Z-IETD-R110

• UNSPSC Description: Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells[1].
• Target Antigen: Fluorescent Dye
• Type: Peptides
• Related Pathways: Others
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/z-ietd-r110.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NC(C=C1)=CC2=C1C(C(C=CC=C3)=C3C([O-])=O)=C(C=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(OCC4=CC=CC=C4)=O)[C@H](CC)C)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)=C5)C5=[O+]2)=O)=O)=O)[C@H]([C@@H](C)CC)NC(OCC6=CC=CC=C6)=O
• Molecular Weight: 1515.53
• References & Citations: [1]Baumgartner H K, et al. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007, 293(1): G296-G307.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported