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Z-IETD-R110

CAT: 0804-HY-P10322Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10322Size:1 Each
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Description
Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells[1].
UNSPSC
12352209
Target
Fluorescent Dye
Type
Peptides
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-ietd-r110.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NC(C=C1)=CC2=C1C(C(C=CC=C3)=C3C([O-])=O)=C(C=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(OCC4=CC=CC=C4)=O)[C@H](CC)C)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)=C5)C5=[O+]2)=O)=O)=O)[C@H]([C@@H](C)CC)NC(OCC6=CC=CC=C6)=O
Molecular Formula
C74H86N10O25
Molecular Weight
1515.53
References & Citations
[1]Baumgartner H K, et al. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007, 293 (1) : G296-G307.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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