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Sarafotoxin S6a (TFA)

CAT: 0804-HY-P1112ASize: 1 EachDry Ice: NoHazardous: No
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Description
Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3. Sarafotoxin S6a TFA elicits the pig coronary artery with an EC50 value of 7.5 nM[1].
UNSPSC
12352209
Target
Endothelin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sarafotoxin-s6a-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O)=O)[C@H](CC)C)=O)C(C)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC3=CN=CN3)[C@H]4NC([C@H](CC5=CC=CC=C5)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@]6(NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@]([H])([C@@H](C)O)NC([C@H](CCSC)NC([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@@]([H])(NC([C@H](CO)NC([C@@H](N)CSSC4)=O)=O)CSSC6)=O)=O)=O)=O)=O)=O)=O)=O)[H])=O)=O)=O)=O
Molecular Formula
C105H156N28O34S5.xC2HF3O2
Molecular Weight
2514.85 (free acid)
References & Citations
[1]P Schoeffter, et al. Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur J Pharmacol
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
ETA; ETB

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T75807-01Sarafotoxin S6a TFA
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