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PF-04979064

CAT: 0804-HY-100398-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100398-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.
CAS Number
1220699-06-8
UNSPSC
12352005
Hazard Statement
H301
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PF-04979064.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C(N1C2CCN(C([C@@H](O)C)=O)CC2)N(C)C3=C1C4=NC(C5=CC=C(C)N=C5)=CC=C4N=C3
Molecular Formula
C24H26N6O3
Molecular Weight
446.50
Precautions
H301
References & Citations
[1]Cheng H et al. Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett, 2012 Nov 7, 4 (1) :91-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PI3Kα; PI3Kγ; PI3Kδ

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