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PF-06647263

CAT: 0804-HY-111965-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111965-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-06647263 is an ADC targeting EFNA4, consisting of EFNA4 Antibody , ADC toxin Calicheamicin (HY-19609) and a linker. PF-06647263 exhibits anti-tumor activity and induces significant tumor regression in TNBC xenografts[1][2].
CAS Number
1822383-65-2
Product Name Alternative
Anti-EFNA4-ADC
UNSPSC
12352211
Target
Antibiotic; Antibody-Drug Conjugates (ADCs) ; Apoptosis; DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-06647263.html
Smiles
[PF-06647263]
References & Citations
[1]Garrido-Laguna I, et al. First-in-human, phase I study of PF-06647263, an anti-EFNA4 calicheamicin antibody-drug conjugate, in patients with advanced solid tumors. Int J Cancer. 2019 Oct 1;145 (7) :1798-1808. |[2]Damelin M, et al. Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions. Clin Cancer Res. 2015 Sep 15;21 (18) :4165-73.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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Alternative Products

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GTR18608540-01PF-06647263 Antibody
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