PROTAC ER Degrader-11

• UNSPSC Description:

  PROTAC ER Degrader-11 (Example 26-1) is a potent PROTAC ER degrader, with the IC50 of 0.66 nM. PROTAC ER Degrader-11 plays an important role in cancer research(Sturcture Note:(Blue: Cereblon ligand (HY-W797329), Black: linker (HY-W262798)；Pink: ER ligand (HY-168271))[1].

• Target Antigen:

  Estrogen Receptor/ERR; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-er-degrader-11.html

• Smiles:

  CC(C)C[C@@H]1[C@H](C2=CC=C(N3CCC(CC3)CN4CCN(C5=CC=C(C(N([C@@H]6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)C=C2)C8=CC=C(O)C=C8CC1

• Molecular Weight:

  703.91

• References & Citations:

  [1] Jiangsu Hengrui Pharmaceuticals Co., Ltd, et al. Tetrahydronaphthalene compound, and preparation method therefor and use thereof in medicine. World Intellectual Property Organization, WO2022206737 A1 2022-10-06

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2846112-04-5