Human GITR / TNFRSF18 Protein, His Tag (MALS verified)

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CAT:

716-GIR-H5228-1mg

Size:

1 mg

Price:

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Human GITR / TNFRSF18 Protein, His Tag (MALS verified)

Background: Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Description: Human GITR, His Tag (GIR-H5228) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).
Specifications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.4 kDa. The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expression Region: Gln 26 - Glu 161
Host: HEK 293
Target: GITR
Conjugation: Unconjugated
Tag: C-6×His
Source: Human
Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin: 1.0 EU per μg
Purity: 92%
Bioactivity: Immobilized Biotinylated Human GITR Ligand, Avitag,Fc Tag (Cat. No. GIL-H82F8) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human GITR, His Tag (Cat. No. GIR-H5228) with a linear range of 0.6-39 ng/mL (QC tested).
Format: Powder
Buffer: PBS, pH7.4
Additives: Trehalose
Molecular Weight: 16.4 kDa
Shipping Conditions: Room Temperature
Storage Conditions: -20°C

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