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GITR Antibody / TNFRSF18

CAT: 0800-R32938Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32938Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL
UniProt
Q9Y5U5
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
A recombinant human protein corresponding to amino acids L178-V241 was used as the immunogen for the GITR antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the GITR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This GITR antibody is available for research use only.
Storage Conditions
After reconstitution, the GITR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the GITR antibody should be determined by the researcher.
Prediction Reactivity
Human
Image Legend
Western blot testing of 1) rat kidney and 2) mouse kidney using GITR antibody at 0.5ug/ml. Predicted molecular weight ~26 kDa.

UniProtKB · Q9Y5U5

Tumor necrosis factor receptor superfamily member 18

TNR18_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y5U5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF18
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B1AME1, O95851, Q5U0I4, Q9NYJ9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoprotein

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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