GITR Antibody / TNFRSF18

GITR Antibody / TNFRSF18

• Description: GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
• CAS Number: 9007-83-4
• UniProt: O35714 (Mouse)
• Host: Rat
• Immunogen: Mouse CD25+ CD4+ T cells were used as the immunogen for the GITR antibody.
• Clonality: Monoclonal
• Isotype: IgG2b λ
• Applications: FACS, IF
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
• Reconstitution: Store the GITR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This GITR antibody is available for research use only.