TMPRSS2 Human Recombinant

TMPRSS2 Human Recombinant _x000D_ Catalog number: B2016914_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 µg_x000D_ Molecular Weight or Concentration: 29.4 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Epitheliasin, PRSS10, Serine Protease 10, Transmembrane Protease Serine 2, Transmembrane Serine Protease 2_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: TMPRSS2 enzymatic activity SARS-CoV-2 Assays [Internet]. Bethesda (MD): National Center for Advancing Translational Sciences (NCATS); 2020–._x000D_ 2: Saunders N, Fernandez I, Planchais C, Michel V, Rajah MM, Baquero Salazar E, Postal J, Porrot F, Guivel-Benhassine F, Blanc C, Chauveau-Le Friec G, Martin A, Grzelak L, Oktavia RM, Meola A, Ahouzi O, Hoover-Watson H, Prot M, Delaune D, Cornelissen M, Deijs M, Meriaux V, Mouquet H, Simon-Lorière E, van der Hoek L, Lafaye P, Rey F, Buchrieser J, Schwartz O. TMPRSS2 is a functional receptor for human coronavirus HKU1 Nature. 2023 Dec;624(7990):207-214._x000D_ 3: Essalmani R, Jain J, Susan-Resiga D, Andréo U, Evagelidis A, Derbali RM, Huynh DN, Dallaire F, Laporte M, Delpal A, Sutto-Ortiz P, Coutard B, Mapa C, Wilcoxen K, Decroly E, Nq Pham T, Cohen ÉA, Seidah NG. Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity J Virol. 2022 Apr 27;96(8):e0012822._x000D_ 4: Wang TH, Huang KY, Chen CC, Chang YH, Chen HY, Hsueh C, Liu YT, Yang SC, Yang PC, Chen CY. PM2.5 promotes lung cancer progression through activation of the AhR-TMPRSS2-IL18 pathway EMBO Mol Med. 2023 Jun 7;15(6):e17014._x000D_ 5: Wettstein L, Kirchhoff F, Münch J. The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment Int J Mol Sci. 2022 Jan 25;23(3):1351._x000D_ 6: Abbasi AZ, Kiyani DA, Hamid SM, Saalim M, Fahim A, Jalal N. Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2 J Med Virol. 2021 Jul;93(7):4205-4218._x000D_ 7: Zipeto D, Palmeira JDF, Argañaraz GA, Argañaraz ER. ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 Front Immunol. 2020 Oct 7;11:576745._x000D_ 8: Dong M, Zhang J, Ma X, Tan J, Chen L, Liu S, Xin Y, Zhuang L. ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19 Biomed Pharmacother. 2020 Nov;131:110678._x000D_ 9: Metzdorf K, Jacobsen H, Greweling-Pils MC, Hoffmann M, Lüddecke T, Miller F, Melcher L, Kempf AM, Nehlmeier I, Bruder D, Widera M, Ciesek S, Pöhlmann S, Čičin-Šain L. TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection Viruses. 2023 Jan 18;15(2):271._x000D_ 10: Thunders M, Delahunt B. Gene of the month: TMPRSS2 (transmembrane serine protease 2) J Clin Pathol. 2020 Dec;73(12):773-776. _x000D_ _x000D_ Products Related to TMPRSS2 Human Recombinant can be found at Proteins

9000-83-3

Catalog Number: B2016914 (10 µg)

0.15

2

0.5