Human CES2 (recombinant)

• Description:

  Human CES2 (recombinant)_x000D_ Catalog number: B2016806_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 60.4 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Carboxylesterase 2, CE-2, Cocaine Esterase, Methylumbelliferyl-acetate Deacetylase 2_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Honda S, Fukami T, Tsujiguchi T, Zhang Y, Nakano M, Nakajima M. Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC Eur J Pharm Sci. 2021 Jun 1;161:105807._x000D_ 2: Wang J, Williams ET, Bourgea J, Wong YN, Patten CJ. Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2 Drug Metab Dispos. 2011 Aug;39(8):1329-33._x000D_ 3: Chalhoub G, Jamnik A, Pajed L, Kolleritsch S, Hois V, Bagaric A, Prem D, Tilp A, Kolb D, Wolinski H, Taschler U, Züllig T, Rechberger GN, Fuchs C, Trauner M, Schoiswohl G, Haemmerle G. Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism Mol Metab. 2023 Jun;72:101725._x000D_ 4: Honda S, Fukami T, Hirosawa K, Tsujiguchi T, Zhang Y, Nakano M, Uehara S, Uno Y, Yamazaki H, Nakajima M. Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans Drug Metab Dispos. 2021 Sep;49(9):718-728._x000D_ 5: Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3 Drug Metab Dispos. 2004 May;32(5):505-11._x000D_ 6: Shen Y, Eades W, Liu W, Yan B. The COVID-19 Oral Drug Molnupiravir Is a CES2 Substrate: Potential Drug-Drug Interactions and Impact of CES2 Genetic Polymorphism In Vitro Drug Metab Dispos. 2022 Sep;50(9):1151-1160._x000D_ 7: Crow JA, Herring KL, Xie S, Borazjani A, Potter PM, Ross MK. Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids Biochim Biophys Acta. 2010 Jan;1801(1):31-41._x000D_ 8: Yoshida T, Fukami T, Kurokawa T, Gotoh S, Oda A, Nakajima M. Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans Eur J Pharm Sci. 2018 Jan 1;111:167-176._x000D_ 9: Jiang J, Chen X, Zhong D. Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans Front Pharmacol. 2017 Nov 20;8:846._x000D_ 10: Parker RB, Hu ZY, Meibohm B, Laizure SC. Effects of alcohol on human carboxylesterase drug metabolism Clin Pharmacokinet. 2015 Jun;54(6):627-38. _x000D_ _x000D_ Products Related to Human CES2 (recombinant) can be found at Proteins

• Short Description:

  Catalog Number: B2016806 (50 µg)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3