ROCK2 Human Recombinant

• Description:

  ROCK2 Human Recombinant _x000D_ Catalog number: B2016815_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 µg_x000D_ Molecular Weight or Concentration: 48.3 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: KIAA0619, Rho-associated Coiled-coil-containing Protein Kinase 2, Rho-associated Protein Kinase 2, Rho Kinase 2, p164 ROCK2_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Zanin-Zhorov A, Blazar BR. ROCK2, a critical regulator of immune modulation and fibrosis has emerged as a therapeutic target in chronic graft-versus-host disease Clin Immunol. 2021 Sep;230:108823._x000D_ 2: Mani S, Jindal D, Chopra H, Jha SK, Singh SK, Ashraf GM, Kamal M, Iqbal D, Chellappan DK, Dey A, Dewanjee S, Singh KK, Ojha S, Singh I, Gautam RK, Jha NK. ROCK2 inhibition: A futuristic approach for the management of Alzheimer's disease Neurosci Biobehav Rev. 2022 Nov;142:104871._x000D_ 3: Zheng K, Hu F, Zhou Y, Zhang J, Zheng J, Lai C, Xiong W, Cui K, Hu YZ, Han ZT, Zhang HH, Chen JG, Man HY, Liu D, Lu Y, Zhu LQ. miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease Nat Commun. 2021 Mar 26;12(1):1903._x000D_ 4: Peng L, Sang H, Wei S, Li Y, Jin D, Zhu X, Li X, Dang Y, Zhang G. circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2 Mol Cancer. 2020 Nov 5;19(1):156._x000D_ 5: Matoba K, Takeda Y, Nagai Y, Sekiguchi K, Ukichi R, Takahashi H, Aizawa D, Ikegami M, Tachibana T, Kawanami D, Kanazawa Y, Yokota T, Utsunomiya K, Nishimura R. ROCK2-induced metabolic rewiring in diabetic podocytopathy Commun Biol. 2022 Apr 8;5(1):341._x000D_ 6: Nalkurthi C, Schroder WA, Melino M, Irvine KM, Nyuydzefe M, Chen W, Liu J, Teng MWL, Hill GR, Bertolino P, Blazar BR, Miller GC, Clouston AD, Zanin-Zhorov A, MacDonald KPA. ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis JHEP Rep. 2021 Oct 6;4(1):100386._x000D_ 7: ROCK2 agent stops GVHD Nat Biotechnol. 2021 Nov;39(11):1323._x000D_ 8: Liu Q, Li HY, Wang SJ, Huang SQ, Yue Y, Maihemuti A, Zhang Y, Huang L, Luo L, Feng KN, Wu ZK. Belumosudil, ROCK2-specific inhibitor, alleviates cardiac fibrosis by inhibiting cardiac fibroblasts activation Am J Physiol Heart Circ Physiol. 2022 Jul 1;323(1):H235-H247._x000D_ 9: Fırat E, Aybek Z, Aybek H. ADRB3, ROCK2, and GEF Levels in Overactive Bladder Patients Int Neurourol J. 2022 Feb;26(Suppl 1):S8-14._x000D_ 10: Tlili A, Pintard C, Hurtado-Nedelec M, Liu D, Marzaioli V, Thieblemont N, Dang PM, El-Benna J. ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2209184120. _x000D_ _x000D_ Products Related to ROCK2 Human Recombinant can be found at Proteins

• Short Description:

  Catalog Number: B2016815 (10 µg)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3