KNK 437

• Background:

  KNK 437 is an inhibitor of the acquisition of thermotolerance caused by the induction of HSPs, including HSP105, HSP70, and HSP40 in human colon carcinoma cells (1). It has also been tested in anti-tumor therapy of colorectal cancer (2).

• Description:

  HSP70 Inhibitor

• Product Name Alternative:

  3- (1,3-Benzodioxol-5-ylmethylene) -2-oxo-1-pyrrolidinecarboxaldehyde

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Heat Shock

• Purity:

  >98% (HPLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Off-white powder

• Solubility:

  May be dissolved in DMSO (30 mg/ml)

• Molecular Formula:

  C13H11NO4

• Molecular Weight:

  245.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Yokota S., Kitahara M., and Nagata K. (2000) Cancer Res. 60 (11): 2942-2948. 2. Yang S., et al. (2020) Oncogene. 39: 249-261.

• CAS Number:

  218924-25-5