HFI-437

• Description:

  HFI-437 is a potent non-peptidic insulin-regulated aminopeptidase (IRAP) inhibitor with a Ki of 20 nM. HFI-437 is a cognitive enhancer[1].

• UNSPSC:

  12352005

• Target:

  Aminopeptidase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hfi-437.html

• Purity:

  99.64

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=C (NC (C) =O) OC2=CC (O) =CC=C2C1C3=CN=C4C=CC=CC4=C3) OCC

• Molecular Formula:

  C23H20N2O5

• Molecular Weight:

  404.42

• References & Citations:

  [1]Anthony L Albiston, et al. Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. FASEB J. 2008 Dec;22 (12) :4209-17.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1110650-74-2