DS-5272

• Description :

  DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53) . DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice[1].

• CAS Number :

  [1235575-97-9]

• UNSPSC :

  12352005

• Target :

  Apoptosis; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ds-5272.html

• Smiles :

  O=C([C@H]1N(C(C2=C(C(C)C)N3C(S2)=N[C@@](C)(C4=CC=C(Cl)N=C4)[C@H]3C5=CC=C(Cl)C(F)=C5)=O)C[C@H](F)C1)N(C6)[C@H](CC)CNC76CC7

• Molecular Formula :

  C34H38Cl2F2N6O2S

• Molecular Weight :

  703.67

• References & Citations :

  [1]Miyazaki M, et al., Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor. Bioorg Med Chem. 2015 May 15;23 (10) :2360-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported