DS-5272

CAT: 0804-HY-120667-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120667-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53) . DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice[1].
CAS Number
[1235575-97-9]
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds-5272.html
Smiles
O=C([C@H]1N(C(C2=C(C(C)C)N3C(S2)=N[C@@](C)(C4=CC=C(Cl)N=C4)[C@H]3C5=CC=C(Cl)C(F)=C5)=O)C[C@H](F)C1)N(C6)[C@H](CC)CNC76CC7
Molecular Formula
C34H38Cl2F2N6O2S
Molecular Weight
703.67
References & Citations
[1]Miyazaki M, et al., Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor. Bioorg Med Chem. 2015 May 15;23 (10) :2360-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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