DS-7423

CAT: 0931-MF-0093167-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0093167-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1222104-37-1
Target
PI3K|||mTOR
Related Pathways
PI3K/Akt/mTOR signaling
Purity
0.9998
Bioactivity
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM and 34.9 nM for PI3K? and mTOR, respectively, and exhibits anti-tumor activity[1][2]. It increases TP53 expression, the level of p-TP53 on Ser-46, and induces apoptosis-related TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1]. DS-7423 also inhibits other isoforms of class I PI3K with IC50 values of 1,143 nM for PI3K?, 249 nM for PI3K?, and 262 nM for PI3K?[2]. [1]. Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42 (7) :757-62. [2]. Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9 (2) :e87220.
Smiles
C[C@@H]1CN(CCN1C(C)=O)c1nc2c(nc(nc2n1CC(F)(F)F)-c1cnc(N)nc1)N1CCOCC1
Molecular Formula
C22H27F3N10O2
Molecular Weight
520.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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