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Homocarnosine (TFA)

CAT: 0804-HY-114883A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114883A-01Size:5 mg
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Description
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1]. Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2].
CAS Number
2991254-59-0
Product Name Alternative
L-Homocarnosine (TFA)
UNSPSC
12352005
Target
Endogenous Metabolite; GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/homocarnosine-tfa.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C(F)(F)F.O=C([C@@H](NC(CCCN)=O)CC1=CNC=N1)O
Molecular Formula
C12H17F3N4O5
Molecular Weight
354.28
References & Citations
[1]Petroff OA, et al. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998;44 (6) :948-952.|[2]Kumrungsee T, et al. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles. Amino Acids. 2020;52 (5) :743-753.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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